diff --git a/gpio/Cargo.toml b/gpio/Cargo.toml
index 28ae5c2..07cc8b2 100644
--- a/gpio/Cargo.toml
+++ b/gpio/Cargo.toml
@@ -24,6 +24,7 @@ virtio-queue = "0.2"
 vm-memory = "0.7"
 vmm-sys-util = "=0.9.0"
 
+[target.'cfg(target_env = "gnu")'.dependencies]
 libgpiod = { git = "https://github.com/vireshk/libgpiod" }
 
 [dev-dependencies]
diff --git a/gpio/src/main.rs b/gpio/src/main.rs
index 3531af3..045cea3 100644
--- a/gpio/src/main.rs
+++ b/gpio/src/main.rs
@@ -5,10 +5,21 @@
 //
 // SPDX-License-Identifier: Apache-2.0
 
+#[cfg(target_env = "gnu")]
 mod backend;
+#[cfg(target_env = "gnu")]
 mod gpio;
+#[cfg(target_env = "gnu")]
 mod vhu_gpio;
 
+#[cfg(target_env = "gnu")]
 fn main() -> backend::Result<()> {
     backend::gpio_init()
 }
+
+// Rust vmm container (https://github.com/rust-vmm/rust-vmm-container) doesn't
+// have tools to do a musl build at the moment, and adding that support is
+// tricky as well to the container. Skip musl builds until the time pre-built
+// libgpiod library is available for musl.
+#[cfg(target_env = "musl")]
+fn main() {}