diff --git a/tests/test_cuse b/tests/test_cuse
index 1b9daa48..5258274c 100644
--- a/tests/test_cuse
+++ b/tests/test_cuse
@@ -11,6 +11,12 @@ if [ "$(id -u)" -ne 0 ]; then
 	exit 77
 fi
 
+if [ -z "$(grep -E '#[[:blank:]]*define[[:blank:]]+WITH_CUSE[[:blank:]]+1[[:blank:]]*$' \
+		   ${PWD}/../config.h)" ]; then
+	echo "Skipping test: swtpm was not compiled with CUSE interface"
+	exit 77
+fi
+
 if [ ! -c /dev/cuse ]; then
 	modprobe cuse
 	if [ $? -ne 0 ]; then